Capsular Polysaccharide of Group A Streptococcus

Streptococcus suis Capsular Polysaccharide Inhibits Phagocytosis through

6 Mathieu Houde, Marcelo Gottschalk, Fleur Gagnon, Marie-Rose Van Calsteren, and 7 Mariela Segura* 8 9 10 Groupe de Recherche sur les Maladies Infectieuses du Porc and Centre de Recherche en 11 Infectiologie Porcine, Faculté de médecine vétérinaire, Université de Montréal, and Food 12 Research and Development Centre, Agriculture and Agri-Food Canada, Saint-Hyacinthe, 13 Québec, Canada. 14 15 16...

Synthesis of capsular polysaccharide (hyaluronic acid) by protoplastmembrane preparations of group A Streptococcus.

Previous reports from this laboratory demonstrated the synthesis of hyaluronic acid by a cell-free preparation obtained from a strain of Group A streptococcus. The enzymic activity which sedimented at 105,000 x g, but not at 10,000 x g, required the addition of uridine diphospho-N-acetylglucosamine, uridine diphosphoglucuronic acid, and Mg++ for the formation of hyaluronic acid (l-3). Since hya...

Structure of a protective epitope of group B Streptococcus type III capsular polysaccharide.

Despite substantial progress in the prevention of group B Streptococcus (GBS) disease with the introduction of intrapartum antibiotic prophylaxis, this pathogen remains a leading cause of neonatal infection. Capsular polysaccharide conjugate vaccines have been tested in phase I/II clinical studies, showing promise for further development. Mapping of epitopes recognized by protective antibodies ...

A model of high-affinity antibody binding to type III group B Streptococcus capsular polysaccharide.

We recently reported that the single repeating-unit pentasaccharide of type III group B Streptococcus (GBS) capsular polysaccharide is only weakly reactive with type III GBS antiserum. To further elucidate the relationship between antigen-chain length and antigenicity, tritiated oligosaccharides derived from type III capsular polysaccharide were used to generate detailed saturation binding curv...

Structural determination of the capsular polysaccharide antigen of type II group B Streptococcus.